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KMID : 1098420110190050334
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Korean Journal of Medicinal Crop Science
2011 Volume.19 No. 5 p.334 ~ p.340
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Effect of Plant Part Extracts of Lythrum salicaria L. on Chronically Alcohol-Administrated Rat
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Lee Seung-Eun
Kim Geum-Soog
Lee Jeong-Hoon
Kang Yong-Ku
Lee Eun-Suk
Choi Je-Hun
Lee A-Reum
Noh Hyung-Jun
Kim Seung-Yu
Park Su-Jin
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Abstract
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The study was done to investigate the effects of the extracts from the different parts of Lythrum salicaria (LS) on liver protective activities in chronically alcohol-treated rats. SD male rats except normal animals were administrated with alcohol ( of 30%~40% ethanol/kg/day) and the extracts (300 mg/kg/day) for 10 weeks. Chronic alcohol administration decreased body weight, high density lipoprotein (HDL)-cholesterol and the reduced form-glutathione (GSH), whereas increased the ethanol content, glutamic-oxaloacetic transaminase (GOT), total cholesterol, low density lipoprotein (LDL)- cholesterol, triglyceride in blood/serum and the ratio of the oxidized form of glutathione (GSSG) and total GSH (GSSG/total GSH) in liver tissue. Groups treated with the extracts of leaf, root and stem, showed decrease in GOT, total cholesterol and GSSG/total GSH and increase in hepatic aldehyde dehydrogenase (ALDH), total GSH and serum albumin. Administration with the root extract of LS decreased blood ethanol content compared with the other part extracts. But, serum triglyceride values in rats treated with root and stem extract were higher than that of the negative control animals. Flower extract-fed group showed decrease in body weight and serum triglyceride, but increase in the ratio of GOT and glutamic-pyruvic transaminase (GPT), and GSSG/total GSH. From the results, we conclude that the extracts of root and leaf among the plant parts of LS might be useful for the amelioration of the chronic alcohol-induced liver demage of rat.
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KEYWORD
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Lythrum salicaria, Alcohol, Liver Damage
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